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Poli, F., Ribet, V., Lauze, C., Adhoute, H. & Morinet, P. (2005). These effects are largely down to the polyphenols (antioxidant molecules) that are naturally present in green tea. But, that doesn’t mean these two can’t be part of your anti-acne routine, as well. Gycolic toner, pure L Absorbic Acid powder mix with a snail mucin and a Vit C serum (Andalou) with a Vit C E Ferulic oil?? A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and improve hydration [30]. ‘Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety’. Posted 12:27 am by & filed under .-sunscreen With antioxidants like vitamin C and E working in tandem to undo the damage caused by UV rays, you’re probably thinking how it makes Layering and mixing skincare ingredients can be overwhelming at the best of times. For example, 2% NAG, alone, reduced the appearance of facial hyperpigmentation, but this reduction was far greater when 2% NAG was combined with 4% niacinamide [61]. Keen, M. & Hassan, I. Using niacinamide and salicylic acid together. (2010). Niacinamide is ok to be used with a gentle vitamin C derivative ex: ascorbyl acid as opposed to a pure/ethylated Ascorbic Acid. Furthermore, the retinaldehyde and glycolic acid formulation can enhance the effects of these other acne treatments, N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production, However, NAG can be unstable when used alone, Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes. Do yourself a favor and go for a bottle that already combines the two ingredients, like the cult favorite Skinceuticals C E Ferulic With 15% L-Ascorbic Acid. However, the above research proves that this is not necessarily the case. This also means that salicylic acid can access sebaceous glands and reduce sebum production [6]. Wang, C., Huang, C., Hu, C. & Chan, H. (1997). However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements [42]. Chamlin, S., Kao, J., Frieden, I. et al. (2005). Photobiol. Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier [29]. Niacinamide and hyaluronic acid, together, are a super skincare combination as they complement each other’s hydrating effects. Davies, M. & Marks, R. (1976). Acne Scars vs Acne Marks | A Guide To The Different Causes & Treatment Options. Davis, E. & Callender, V. (2010). When used together, start by applying hyaluronic acid then followed by niacinamide. Add number 2 to all these products if you have them. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use [2]. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. They basically ‘mop-up’ the damage done by UV radiation and other environmental aging factors (smoking, pollution, etc.) Or maybe, just maybe, will they enhance each other and let us experience the glowing skin that we have only ever dreamed of? Another great skincare ingredient combination for hyperpigmentation and melasma is glycolic acid and resveratrol. 12 Derm-Approved Drugstore Products To Try, The Only 4 Skincare Ingredients You Actually Need, What You Need to Know Before a Casual Hookup, What You Should Know Before You Say That Someone Looks 'Anorexic', A Top Derm Shares Her Pregnancy Skincare Routine, Things You Should Know BEFORE You Visit the Gyno. ‘Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin’. ‘Preliminary open-label clinical evaluation of the soothing and reepithelialisation properties of a novel topical formulation for rosacea’. “It’s essential for collagen production, which gives our skin support and structure to combat fine lines and wrinkles,” Dr. Libby says. ‘Effects of Visible Light on the Skin’. (1991). Niacinamide, a water-soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. & Herman, A. Another problem with mixing niacinamide and acid is that it can cause redness and flushing. of niacinamide and salicylic acid by first forming a pre-neutralized ionic solid of the two molecules and then rapidly spray-drying the two molecules at a 1:1 ratio with a small amount (1%) of a polysaccharide encapsulant. & Brody, N. (2011). Hydroxy acids are particularly useful for treating acne [1]. Niacinamide and Hyaluronic Acid Together. (2013). Loden, M. (2016). This can be in a toner or serum form. & Gajjar, A. ‘An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses’, Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. Buy Bliss Clear Genius Clarifying Toner + Serum, Gently Tone & Soothe Skin, Witch Hazel, Niacinamide, Salicylic Acid and CICA Clear and Minimize Pores, Clarifies Skin, Cruelty-Free & Vegan, 4.3 fl oz on Amazon.com FREE SHIPPING on qualified orders 82, 1123– 1131. As it’s so harsh on its own, it’s not a good idea to use it together with salicylic acid or retinoids. Products That Combine Green Tea & Caffeine: Our skin’s hydration generally depends on two major factors; the presence of natural moisturising factors and the structure and composition of the lipids in the stratum corneum. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration [28]. Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. Bonus tips: Drink lots of water. ‘The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast’. So will ingredient X counteract our ingredient Y? (2014). (2008). Products That Combine Glycolic Acid & Resveratrol: Retinol is a derivative of vitamin A that can increase the rate of skin cell turnover and renewal, reduce sun damage, boost collagen production, improve the appearance of wrinkles, reduce pigmentation, and increase skin hydration [49]. Then slather on a serum like The Ordinary Niacinamide 10% + Zinc 1%. Other research has found that this is an additive effect. Sound simple enough, right? (2005). I always thought that Retinol and AHA could NOT be used together??? As you can see, niacinamide and salicylic acid offer similar benefits but work in slightly different ways. Salicylic Acid And Retinol Together: Benefits, Risks, & Myths. ‘The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells’. Al-Niaimi, F. & Chiang, N. (2017). Salicylic, glycolic, and lactic acids are all effective exfoliants that can improve skin … ‘Interaction of vitamins C and E as better cosmeceuticals’. vitamin B3) comes in. To start, it’s safest to use alpha hydroxy acids (like glycolic) or beta hydroxy acids (like salicylic) twice a week, but not on the same nights that you use a retinol. Sunscreen + Antioxidants = Increased Photoprotection. ‘Treatments Improving Skin Barrier Function’. Among ingredient MVPs, vitamin C tops the list. Products That Combine N-Acetyl Glucosamine & Niacinamide: We have discussed 12 examples of skincare ingredient combinations where less is not more. Acids have a low pH of 3-4, whereas niacinamide has a higher pH at around 5-7. This means that combining the two can have an additive effect. Kameyama, K., Sakai, C., Kondoh, S. et al. Ash, K., Lord, J., Zukowskl, M. & McDaniel, D. (2013). Golden, G., Guzek, D., Kennedy, A., McKie, J. Basically, the addition of vitamins A, C, and E with centella asiatica didn’t increase the production of collagen anymore than when vitamin C was added to centella asiatica on its own. Sincerely. In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding) [46]. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion [3]. (2013). I did learn alot from reading your article. Infrared radiation accounts for about 53% and, Unfortunately, sunscreen is only able to block about 55% of the free radicals produced by UV exposure, and, alone, provides no protection from the free radicals produced by either infrared radiation or visible light, When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. Salicylic acid (also known as beta hydroxy acid, or BHA) and retinol can do serious magic for skin, and there’s no better time to pair them together — for a few reasons. All content, including, but not limited to, text, images, links, and other material does not constitute medical or other professional advice, and is not intended to be a substitute for professional medical advice. Vitamins C and E will tag-team to increase protection for your skin and limit UV ray–induced damage. How can you tell the difference? This means you can use niacinamide and vitamin C together without any problem. Your skin’s hydration is controlled by the outermost layer of your epidermis, … Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C, Centella Asiatica + Vitamin A + Vitamin C + Vitamin E = 3x, Centella Asiatica + Vitamin C + Glycolic Acid = 4x, Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. Can You Use Hyaluronic Acid And Glycolic Acid Together? In the Should Niacinamide and L-Ascorbic Acid Be Used Together post, it was shown that the two compounds don’t mesh well: a 1:1 complex would form in solution (aqueous), with a maximum complexation rate occurring at a pH of 3.8. Lol. When in doubt, just introduce one active-boosted product at a time. Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness [55]. Because NAG and niacinamide target pigmentation in two separate ways (NAG prevents melanin production while niacinamide prevents the spread of existing melanin), they are highly likely to compliment each other when used together. Usuki, A., Ohashi, A., Sato, H., Ochiai, Y., Ichihashi, M. & Funasaka, Y. Kimball, A., Kaczvinsky, J., Li, J., Robinson, L. et al. AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Milstone, L. (2004). ‘RALGA (Diacneal), a retinaldehyde and glycolic acid association and post-inflammatory hyperpigmentation in acne – a review’. In fact, it can actually stop the visible signs of skin aging when used correctly [7]. As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle [5]. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2013). She has experience in plastic and reconstructive surgery, dermatology, and aesthetics and has received training in laser treatments. ‘Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in guinea pig skin’. Skincare maximalism was once the norm (10 steps, anyone? Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks [48]. If you decide to combine this masque with other direct acids, we recommend you perform a patch test of … In order to get the maximum benefits from our skincare ingredients, we should look for products that contain the above combinations. This is because both vitamin C and glycolic acid are known to boost collagen levels in the skin and it appears that their effects may be additive. Centella Asiatica + Vitamin C + Glycolic Acid = Increased Collagen Production by 4x. The stacking “helps the retinoid penetrate deeper into the skin to work its magic,” says Dr. Libby. ‘Irradiation of skin with visible light induced reactive oxygen species and matrix degrading enzymes’. I was so confused. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. When used together, they’re more likely to cause redness and irritations. Here’s what skin care ingredients work together and which don’t. ‘Comparitive study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris’. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67%, Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light, This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production, In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. “Vitamin E makes vitamin C four times stronger.” Wow! that is known to reduce pigmentation and inflammation and has anti-aging properties, It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin, Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase, In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding), In addition, glycolic acid is very good at penetrating skin, Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks, When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. Berson, D., Osborne, R., Oblong, J., Hakozaki, T., Jonson, M. & Bissett, D. (2014). Furthermore, the retinaldehyde and glycolic acid formulation can enhance the effects of these other acne treatments [60]. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production [53][45]. ‘Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid’. Hydroxy acids are particularly useful for treating, For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne, Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker. This is all down to the molecular structure of each ingredient." Great for acne breakouts, salicylic acid shrinks them up, and fast. 82, 1123– 1131. When this lipid matrix is depleted, skin can become dehydrated [25] which results in rougher and duller looking skin. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x), In addition, vitamin C is one of the few examples in life where three is not a crowd. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol) [50]. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use, InstaNatural Age Defying Skin Clearing Moisturizer, This is because roughly 80-90% of all facial skin aging is caused by sun damage, This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin, In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with both vitamin E and ferulic acid! Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Products That Combine Ceramides & Cholesterol & Fatty Acids: Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. I recommend you put on benzoyl peroxide in the morning and use salicylic acid and retinoids at night. ‘Hydration effects on the barrier function of stratum corneum lipids: Raman analysis of ceramides 2, III and 5’. ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. Once you decide to use them together, try it for 1-2x a week and so if your skin is able to handle it then you can continue with using it more frequently. Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C [19]. Manela-Azulay, M. & Bagatin, E. (2009). Eventually you can start using them together but again START SLOW. Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne [57]. ‘Nicotinic acid/niacinamide’. In addition, vitamin C is one of the few examples in life where three is not a crowd. The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. ‘Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes’. 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